HUGIn is designed to explore chromatin organizations across multiple human cell lines and primary tissues. HUGIn incorporates data from multiple sources including genetic variants (SNPs), chromatin organization features (including topologically associating domain (TAD) boundaries, frequently interacting regions (FIRE)s, and long-range chromatin interactions from the analysis of Hi-C data) gene expression (from tissue or cell line specific RNA-Seq data), and multiple epigenetic datasets (including information on typical and super enhancers, CTCF binding sites, H3K4me1, H3K4me3, H3K27ac, H3K36me3, H3K27me3 and H3K9me3 peaks). Current data are all mapped to the reference genome hg19 (Genome Reference Consortium GRCh37). For more details and a complete tutorial, please see our Tutorial page.
See data description here.

HiC:

Name Bin Size (in KB) Gene Expression TAD Enhancer FIRe ChIP-Seq CTCF PMID
1 Adrenal 40 1 1 1 1 1 0 27851967
2 Adult Cortex 10 1 0 0 0 0 0 https://doi.org/10.1101/406330
3 Aorta 40 1 1 1 1 1 0 27851967
4 Bladder 40 1 1 1 1 0 0 27851967
5 Dorsolateral Prefrontal Cortex 40 1 1 0 1 1 0 27851967
6 Fetal Cortex 10 1 0 0 0 0 0 https://doi.org/10.1101/406330
7 Fetal Lung Fibroblast Cell 40 1 1 1 1 1 1 27851967
8 Hippocampus 40 1 1 0 1 1 0 27851967
9 Human Embryonic Stem Cell 40 1 1 1 1 1 1 27851967
10 Left Ventricle 40 1 1 1 1 1 0 27851967
11 Liver 40 1 1 0 1 1 0 27851967
12 Lung 40 1 1 1 1 1 0 27851967
13 Lymphoblastoid (Rao 2014) 10 0 0 0 0 0 0 25497547
14 Lymphoblastoid (Schmitt.) 40 1 1 1 1 1 1 27851967
15 Macrophages (Phanstiel) 10 0 0 0 0 0 0 28890333
16 Mesenchymal Cell 40 1 1 0 1 1 1 27851967
17 Mesendoderm Cell 40 1 1 0 1 1 1 27851967
18 Monocytes (Phanstiel) 10 0 0 0 0 0 0 28890333
19 Neural Progenitor 40 1 1 0 1 1 1 27851967
20 Ovary 40 1 1 1 1 1 0 27851967
21 Pancreas 40 1 1 1 1 1 0 27851967
22 Psoas 40 1 1 1 1 1 0 27851967
23 Right Ventricle 40 1 1 1 1 1 0 27851967
24 Small Bowel 40 1 1 1 1 1 0 27851967
25 Spleen 40 1 1 1 1 1 0 27851967
26 Trophoblast-like Cell 40 1 1 0 1 1 1 27851967

HiChIP:

Name Bin Size (in KB) Gene Expression TAD Enhancer FIRe ChIP-Seq CTCF PMID
1 HCASMC (coronary artery smooth muscle; H3K27ac) 10 0 0 0 0 0 0 28945252
2 Leukemia K562 (H3K27ac) 10 0 0 0 0 0 0 28945252
3 Lymphoblastoid (GM12878; H3K27ac) 10 0 0 0 0 0 0 28945252
4 My-La (H3K27ac) 10 0 0 0 0 0 0 28945252
5 Naive T (CTCF) 10 0 0 0 0 0 0 28945252
6 Naive T (H3K27ac) 10 0 0 0 0 0 0 28945252
7 T-helper 17 (H3K27ac) 10 0 0 0 0 0 0 28945252
8 T-reg (H3K27ac) 10 0 0 0 0 0 0 28945252

PC-HiC

Name Has Read Count Gene Expression TAD Enhancer FIRe ChIP-Seq CTCF PMID
1 Activated Total CD4+ T Cells 0 0 0 0 0 0 0 27863249
2 Adrenal Gland (Jung et al.) 1 0 0 0 0 0 0 31501517
3 Aorta (Jung et al.) 1 0 0 0 0 0 0 31501517
4 Astrocyte 1 1 0 0 0 0 0 31367015
5 Bladder (Jung et al.) 1 0 0 0 0 0 0 31501517
6 Cardiomyoctes (Jung et al.) 1 0 0 0 0 0 0 31501517
7 Dorsolateral Prefrontal Cortex (Jung et al.) 1 0 0 0 0 0 0 31501517
8 Endothelial Precursors 0 0 0 0 0 0 0 27863249
9 Erythroblasts 0 1 0 0 0 0 0 27863249
10 Esophagus (Jung et al.) 1 0 0 0 0 0 0 31501517
11 Fat (Jung et al.) 1 0 0 0 0 0 0 31501517
12 Fetal Thymus 0 0 0 0 0 0 0 27863249
13 Fibroblast (Jung et al.) 1 0 0 0 0 0 0 31501517
14 Gastric (Jung et al.) 1 0 0 0 0 0 0 31501517
15 Hippocampus (Jung et al.) 1 0 0 0 0 0 0 31501517
16 Human Embryonic Stem Cell (Jung et al.) 1 0 0 0 0 0 0 31501517
17 Left Ventricle (Jung et al.) 1 0 0 0 0 0 0 31501517
18 Liver (Jung et al.) 1 0 0 0 0 0 0 31501517
19 Lung (Jung et al.) 1 0 0 0 0 0 0 31501517
20 Lymphoblastoid (Jung et al.) 1 0 0 0 0 0 0 31501517
21 Macrophages M0 0 1 0 0 0 0 0 27863249
22 Macrophages M1 0 1 0 0 0 0 0 27863249
23 Macrophages M2 0 1 0 0 0 0 0 27863249
24 Megakaryocytes 0 1 0 0 0 0 0 27863249
25 Mesenchymal Stem Cell (Jung et al.) 1 0 0 0 0 0 0 31501517
26 Mesendoderm (Jung et al.) 1 0 0 0 0 0 0 31501517
27 Monocytes 0 1 0 0 0 0 0 27863249
28 Naive B cells 0 0 0 0 0 0 0 27863249
29 Naive CD4+ T Cells 0 1 0 0 0 0 0 27863249
30 Naive CD8+ T Cells 0 0 0 0 0 0 0 27863249
31 Neural Progenitor Cell (Jung et al.) 1 0 0 0 0 0 0 31501517
32 Neutrophils 0 1 0 0 0 0 0 27863249
33 Non-activated Total CD4+ T Cells 0 0 0 0 0 0 0 27863249
34 Ovary (Jung et al.) 1 0 0 0 0 0 0 31501517
35 Pancreas (Jung et al.) 1 0 0 0 0 0 0 31501517
36 Psoas (Jung et al.) 1 0 0 0 0 0 0 31501517
37 Right Atrium (Jung et al.) 1 0 0 0 0 0 0 31501517
38 Right Ventricle (Jung et al.) 1 0 0 0 0 0 0 31501517
39 Sigmoid Colon (Jung et al.) 1 0 0 0 0 0 0 31501517
40 Small Bowel (Jung et al.) 1 0 0 0 0 0 0 31501517
41 Spleen (Jung et al.) 1 0 0 0 0 0 0 31501517
42 Thymus (Jung et al.) 1 0 0 0 0 0 0 31501517
43 Total B cells 0 0 0 0 0 0 0 27863249
44 Total CD4+ T Cells 0 0 0 0 0 0 0 27863249
45 Total CD8+ T Cells 0 0 0 0 0 0 0 27863249
46 Trophoblast (Jung et al.) 1 0 0 0 0 0 0 31501517
47 iPSC-derived Hippocampal DG-like Neuron 1 1 0 0 0 0 0 31367015
48 iPSC-derived Lower Motor Neuron 1 1 0 0 0 0 0 31367015
49 iPSC-induced Excitatory Neuron 1 1 0 0 0 0 0 31367015